REVIEW PAPER
The role of lifestyle physical activity in preventing multiple sclerosis
 
 
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Department of Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland
 
 
Submission date: 2024-04-03
 
 
Acceptance date: 2024-07-11
 
 
Publication date: 2024-09-30
 
 
Corresponding author
Józef Opara   

The Jerzy Kukuczka Academy of Physical Education, ul. Mikołowska 72b, 40-065 Katowice, Poland
 
 
Hum Mov. 2024;25(3):1-9
 
KEYWORDS
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ABSTRACT
Multiple sclerosis (MS) is a devastating neurodegenerative disorder that affects more than three million people worldwide. Among the environmental, lifestyle, dietary, comorbid, and pharmacological factors investigated as possible modifiable protective or risk factors for MS, physical activity (PA) seems to play a valuable role in its prevention. Currently, there is no comprehensive review article on the preventive effects of PA in MS. This narrative review aimed to evaluate the most recent and extensive pooled analysis and evidence and to explore the influence of lifestyle PA on primary and secondary prevention in MS. Literature articles were searched through several databases, including PubMed, Cochrane Library, Embase, and Web of Science, from 1985 to March 2024. The review focused on lifestyle PA, defined as the daily accumulation of at least 30 min of self-selected activities. This includes all leisure, occupational, or household activities that are at least moderate to vigorous in intensity and may be planned or unplanned activities that are part of everyday life. The most valuable and representative reports on primary and secondary prevention in MS have been selected. Lifestyle PA, practised at moderate and high intensity, plays a protective role in reducing the risk of developing MS and delaying the onset of disability in persons with MS. Future studies are required to identify specific types of PA that are particularly recommended for patients with MS.
 
REFERENCES (34)
1.
Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Napier CA, Rijke N, Baneke P. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020;26(14):1816– 21; doi: 10.1177/1352458520970841.
 
2.
Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985;100(2):126–31.
 
3.
Strath SJ, Kaminsky LA, Ainsworth BE, Ekelund U, Freedson PS, Gary RA, Richardson CR , Smith DT, Swartz AM; American Heart Association Physical Activity Committee of the Council on Lifestyle and Cardiometabolic Health and Cardiovascular, Exercise, Cardiac Rehabilitation and Prevention Committee of the Council on Clinical Cardiology, and Council. Guide to the assessment of physical activity: clinical and research applications: a scientific statement from the American Heart Association. Circulation. 2013;128(20):2259– 79; doi: 10.1161/01.cir.0000435708.67487.da.
 
4.
Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, Coke LA, Fleg JL, Forman DE, Gerber TC, Gulati M, Madan K, Rhodes J, Thompson PD, Williams MA; American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology, Council on Nutrition, Physical Activity and Metabolism, Council on Cardiovascular and Stroke Nursing, and Council on Epidemiology and Prevention. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation. 2013;128(8):873– 934; doi: 10.1161/CIR .0b013e31829b5b44.
 
5.
Kalb R, Brown TR, Coote S, Costello K, Dalgas U, Garmon E, Giesser B, Halper J, Karpatkin H, Keller J, Ng AV, Pilutti LA, Rohrig A, Van Asch P, Zackowski K, Motl RW. Exercise and lifestyle physical activity recommendations for people with multiple sclerosis throughout the disease course. Mult Scler. 2020;26(12):1459–69; doi: 10.1177/13524 58520915629.
 
6.
Bouchard C, Shephard R. Physical activity, fitness, and health: the model and key concepts. In: Bouchard C, Shephard RJ, Stephens T. (eds.) Physical Activity, Fitness, and Health. International Proceedings and Consensus Statement. Champaign: Human Kinetics Publishers; 1994; pp. 77–88; doi: 10.1249/00005768-199401000-00024.
 
7.
Dunn AL, Andersen RE, Jakicic JM. Lifestyle physical activity interventions. History, short- and long-term effects, and recommendations. Am J Prev Med. 1998;15(4):398–412; doi: 10.1016/s07 49-3797(98)00084-1.
 
8.
Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci. 2008;9(1):58–65; doi: 10.1038/nrn2298.
 
9.
Nortvedt MW, Riise T, Maeland JG. Multiple sclerosis and lifestyle factors: the Hordaland Health Study. Neurol Sci. 2005;26(5):334–9; doi: 10.1007/ s10072-005-0498-2. [10] Motl RW, McAuley E, Snook EM. Physical activity and multiple sclerosis: a meta-analysis. Mult Scler. 2005;11:459–63; doi: 10.1191/1352458505ms 1188oa.
 
10.
Ng AV, Kent-Braun JA. Quantitation of lower physical activity in persons with multiple sclerosis. Med Sci Sports Exerc. 1997;29(4):517–23; doi: 10.1097/ 00005768-199704000-00014.
 
11.
Dobson R, Tanasescu R, Gran B. Editorial: preventing multiple sclerosis. Front Neurol. 2022;13: 982411; doi: 10.3389/fneur.2022.982411.
 
12.
Frau J, Coghe G, Lorefice L, Fenu G, Cadeddu B, Marrosu MG, Cocco E. Attitude towards physical activity in patients with multiple sclerosis: a cohort study. Neurol Sci. 2015;36(6):889–93; doi: 10.1007/s10072-015-2100-x.
 
13.
Dorans KS, Massa J, Chitnis T, Ascherio A, Munger KL. Physical activity and the incidence of multiple sclerosis. Neurology. 2016;87(17):1770–1776; doi: 10.1212/WNL.0000000000003260.
 
14.
Wesnes K, Myhr KM, Riise T, Cortese M, Pugliatti M, Boström I, Landtblom A-M, Wolfson C, Bjørnevik K. Physical activity is associated with a decreased multiple sclerosis risk: the EnvIMS study. Mult Scler. 2018;24(2):150–7; doi: 10.1177/ 1352458517694088.
 
15.
Li C, Lin J, Yang T, Xiao Y, Jiang Q, Shang H. Physical activity and risk of multiple sclerosis: a Mendelian randomization study. Front Immunol. 2022;13:872126; doi: 10.3389/fimmu.2022.872 126.
 
16.
Sandroff BM, Dlugonski D, Weikert M, Suh Y, Balantrapu S, Motl RW. Physical activity and multiple sclerosis: new insights regarding inactivity. Acta Neurol Scand. 2012;126(4): 256–62; doi: 10.1111/j.1600-0404.2011.01634.x.
 
17.
Motl RW, Sandroff BM, Pilutti LA, Klaren RE, Baynard T, Fernhall B. Physical activity, sedentary behavior, and aerobic capacity in persons with multiple sclerosis. J Neurol Sci. 2017;372:342–6; doi: 10.1016/j.jns.2016.11.070.
 
18.
Streber R, Peters S, Pfeifer K. Systematic review of correlates and determinants of physical activity in persons with multiple sclerosis. Arch Phys Med Rehabil. 2016;97(4):633–45.e29; doi: 10.1016/j. apmr.2015.11.020.
 
19.
Arntzen EC, Bidhendi-Yarandi R, Sivertsen M, Knutsen K, Dahl SS H, Hartvedt MG, Normann B, Behboudi-Gandevani S. The effect of exercise and physical activity-interventions on step count and intensity level in individuals with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials. Front Sports Act Living. 2023;5:1162278; doi: 10.3389/fspor.2023.11 62278.
 
20.
Gervasoni E, Anastasi D, Di Giovanni R, Solaro C, Rovaris M, Brichetto G, Carpinella I, Confalonieri P, Tacchino A, Rabuffetti M, Cattaneo D. Physical activity in non-disabled people with early multiple sclerosis: a multicenter cross-sectional study. Mult Scler Relat Disord. 2022;64:103941; doi: 10.1016/j.msard.2022.103941.
 
21.
Pedullà L, Santoyo-Medina C, Novotna K, Moumdjian L, Smedal T, Arntzen EC, van der Linden ML, Learmonth Y, Kalron A, Güngör F, Nedeljkovic U, Kos D, Jonsdottir J, Coote S, Tacchino A. Physical activity in multiple sclerosis: meeting the guidelines at the time of the CO VID-19 pandemic. J Neurol Phys Ther. 2023;47(2):112–21; doi: 10.1097/ NPT.0000000000000430.
 
22.
Wanitschek A, Seebacher B, Muehlbacher A, Brenneis C, Ehling R. Comparison of patient-reported outcomes of physical activity and accelerometry in people with multiple sclerosis and ambulatory impairment: a cross-sectional study. Mult Scler Relat Disord. 2024;85:105532; doi: 10.1016/j. msard.2024.105532.
 
23.
Doerksen SE, Motl RW, McAuley E. Environmental correlates of physical activity in multiple sclerosis: a cross-sectional study. Int J Behav Nutr Phys Act. 2007;4:49–55; doi: 10.1186/1479-5868-4-49.
 
24.
Ploughman M. Breaking down the barriers to physical activity among people with multiple sclerosis – a narrative review. Phys Ther Rev. 2017; 22(3–4):124–32; doi: 10.1080/10833196.2017.13 15212.
 
25.
Riemann-Lorenz K, Wienert J, Streber R, Motl RW, Coote S, Heesen C. Long-term physical activity in people with multiple sclerosis: exploring expert views on facilitators and barriers. Disabil Rehabil. 2020;42(21):3059–71; doi: 10.1080/09638 288.2019.1584253.
 
26.
Stuifbergen AK. Physical activity and perceived health status in persons with multiple sclerosis. J Neurosci Nurs. 1997;29(4):238–243; doi: 10.1097/ 01376517-199708000-00004.
 
27.
Dlugonski D, Motl RW, McAuley E. Increasing physical activity in multiple sclerosis: replicating Internet intervention effects using objective and self-report outcomes. J Rehabil Res Dev. 2011;48(9): 1129–1136; doi: 10.1682/jrrd.2010.09.0192.
 
28.
Sangelaji B, Smith CM, Paul L, Sampath KK, Treharne GJ, Hale LA. The effectiveness of behaviour change interventions to increase physical activity participation in people with multiple sclerosis: a systematic review and meta-analysis. Clin Rehabil. 2016;30(6):559–76; doi: 10.1177/02692 15515595274.
 
29.
Opara JA, Brola W, Wylegala AA, Wylegala E. Uhthoff’s phenomenon 125 years later – what do we know today? J Med Life. 2016;9(1):101–5.
 
30.
Motl RW, McAuley E, Wynn D, Sandroff B, Suh Y. Physical activity, self-efficacy, and health-related quality of life in persons with multiple sclerosis: analysis of associations between individual-level changes over one year. Qual Life Res. 2013;22(2): 253–61; doi: 10.1007/s11136-012-0149-z.
 
31.
Beratto L, Bressy L, Agostino S, Malandrone F, Brichetto G, Ponzano M. The effect of exercise on mental health and health-related quality of life in individuals with multiple sclerosis: a systematic review and meta-analysis. Mult Scler Relat Disord. 2024;83:105473; doi: 10.1016/j.msard.2024.105 473.
 
32.
Jeng B, DuBose NG, Martin TB, Šilić P, Flores VA, Zheng P, Motl RW. Updated systematic review and quantitative synthesis of physical activity levels in multiple sclerosis. Am J Phys Med Rehabil. 2024;103(4):284–92; doi: 10.1097/PHM.00000 00000002312.
 
33.
Global Action Plan on Physical Activity 2018–2030. More Active People for a Healthier World. Geneva: WHO; 2018. Available 06.09.2024 from: https:// apps.who.int/iris/bitstream/handle/10665/ 272722/9789241514187-eng.pdf.
 
34.
Bull FC, Al-Ansari SS , Biddle S, Borodulin K, Buman MP, Cardon G, Carty C, Chaput J-P, Chastin S, Chou R, Dempsey PC, DiPietro L, Ekelund U, Firth J, Friedenreich CM, Garcia L, Gichu M, Jago R, Katzmarzyk PT, Lambert E, Leitzmann M, Milton K, Ortega FB, Ranasinghe C, Stamatakis E, Tiedemann A, Troiano RP, van der Ploeg HP, Wari V, Willumsen JF. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54(24):1451–62; doi: 10.1136/bjsports-2020-102955.
 
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